Recently had alot of heart ache load balancing some sharepoint systems.
if you are using any of the cute features in sharepoint that require RFC 2518 http methods like copy, propfind, etc... you need to add the directive
'http-method parse RFC2518-methods'
Or your results will suffer.
if you are running Kerberos for your users, you also need to do increase the number of packets the CSS will span to examine HTTP headers. The default is 6. Enabling kerberos makes the HTTP headers exceed 10 1460 length ethernet frames and consequently users get repeatedly prompted for credentials.
Avoid the suffering with...